Reactivity between rheumatoid factor and rheumatoid tissue.

Reactivity between rheumatoid factor and rheumatoid tissue.

Comparative Measurement of Rheumatoid Factor in Serum and Synovial Fluid of Rheumatoid Arthritis Patients by ELISA and Latex-Agglutination Test

Rheumatoid factors (RF) are autoantibodies with specificity for the Fc portion of human IgG. Production of RF is a characteristic feature of rheumatoid arthritis (RA) and is detectable in high titer in about 90% of these patients. In this study, we measured total IgM, IgA, IgMRF and IgARF in serum and synovial fluid of 45 RA patients by ELISA and the results were compared with those obtained b...

Differential Expression of Rheumatoid Factor-Associated Cross-Reactive Idiotypes in Iranian Seropositive and Seronegative Patients with Rheumatoid Arthritis

High levels of rheumatoid factors (RF) are detectable in serum of the majority of patients with rheumatoid arthritis (RA), but 5-10% of patients remain seronegative (SN). Despite clinical and genetic similarities between these two subsets of RA, it has been proposed that they may be regarded as distinct clinical entities. Methods: In the present study a panel of monoclonal antibodies (mAb) rec...

Rheumatoid arthritis and osteoporosis

Rheumatoid arthritis and osteoporosis

Rheumatoid arthritis : Looking Beyond Rheumatoid Factor

762 IntroductIon Rheumatoid arthritis (RA) is a chronic crippling disease that causes significant morbidity and even mortality. The etiology is not known and hence the diagnosis is based on the typical clinical picture of inflammatory symmetrical polyarthritis supported by imaging and serological investigations. Among the serological investigations, rheumatoid factor (RF) is the most widely use...